Description
Product Characteristics:
Glut4 is a twelve pass transmembrane protein (12TM) whose carboxy-terminus may dictate its cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity. TUG (ASPL in humans) regulates the trafficking of glucose via Glut4. Full-length TUG forms a complex with Glut4 and in 3T3-L1 adipocytes and this complex is present in unstimulated cells and is disassembled by insulin. TUG acts by trapping endocytosed Glut4 and tethering it intracellularly. Insulin mobilizes this pool of retained Glut4 by releasing the tether.
Subcellular location: Cell membrane
Synonyms: Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma chromosome region candidate 1 human, Alveolar soft part sarcoma locus, ASPC, ASPC1_HUMAN, ASPCR 1, ASPCR1, ASPL, ASPS, ASPSCR 1, Aspscr1, FLJ45380, RCC 17, RCC17, renal cell carcinoma gene on chromosome 17, renal cell carcinoma papillary 17, Renal papillary cell carcinoma protein 17, Tether containing a UBX domain for GLUT4, Tether containing UBX domain for GLUT4, TUG, UBX domain containing protein 9, UBX domain protein 9, UBX domain-containing protein 9, UBXD 9, UBXD9, UBXN 9, UBXN9.
Target Information: The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\,17)(p11\,q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]